Welcome to AICARPeptide.com: Your Trusted Source for AICAR Peptide and AMPK Activation Solutions

Revolutionizing Metabolic Research and Performance Optimization

At AICARPeptide.com, we are committed to delivering premium-quality peptides and scientifically-driven insights for researchers, professionals, and enthusiasts dedicated to advancing knowledge and innovation in energy metabolism, muscle glucose metabolism, and overall metabolic health. Our flagship product, AICAR peptide, which is a form of 5 aminoimidazole 4 carboxamide is renowned for its pivotal role in activating AMPK, offering vast potential for studies exploring skeletal muscle function, insulin sensitivity, glucose uptake, and fatty acid oxidation.

Whether your focus is on metabolic pathways in rat skeletal muscle, impacts on adipose tissue, or systemic responses like systolic blood pressure regulation, we aim to support your research journey with exceptional peptides and trustworthy information.

AICAR Peptide: A Cornerstone in Metabolic Research

AICAR peptide—known scientifically as 5 aminoimidazole 4 carboxamide ribofuranoside AICAR—has garnered considerable attention for its ability to activate amp activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. AMPK functions as a metabolic “switch,” responding to changes in cellular energy by shifting processes towards oxidative metabolism, fatty acid oxidation, and enhanced glucose uptake.

Previous studies have highlighted AICAR’s effects across multiple tissue types, including gastrocnemius muscles, rat hepatocytes, isolated hepatocytes, and even endothelial cells. By simulating metabolic stress in both regular and obese rats , AICAR can influence cellular energy balance, driving significant metabolic adaptations and changes in protein levels crucial for understanding metabolic diseases and athletic performance.

Understanding AMPK and Its Impact

AMPK: The Metabolic Master Switch

AMP activated protein kinase (AMPK) is central to the regulation of energy metabolism in both human and animal models. When cellular energy drops, such as during exercise, fasting, or metabolic stress, AMPK becomes activated, prompting the cell to:

• Increase glucose uptake
• Boost fatty acid oxidation
• Suppress fatty acid synthesis
• Promote mitochondrial biogenesis and mitochondrial function
• Enhance muscle metabolism

These processes are essential not only for maintaining metabolic homeostasis but also for combating conditions like insulin resistance, obesity, and other metabolic disorders.

AICAR’s Influence on Skeletal Muscle and Metabolism

Muscle Contraction and AICAR Activation

Research has consistently shown that muscle contraction itself is a potent activator of AMPK. Interestingly, AICAR peptide can mimic some of the cellular responses observed during physical activity and exercise training, leading to:

• Increased glucose uptake in skeletal muscle
• Elevated fatty acid oxidation
• Reduction in fat mass

In rat skeletal muscle, AICAR administration has demonstrated beneficial effects on insulin stimulated glucose uptake, mirroring improvements often attributed to regular physical activity. This makes AICAR an invaluable tool in exploring muscle glucose metabolism and the underlying molecular mechanisms involved in insulin sensitivity and glucose tolerance.

AICAR and Obesity Research

Impact on Obese Animal Models

Studies investigating obese Zucker rats, genetically obese models, and other obese animals have documented significant shifts in metabolic adaptations following aicar administration. In such models:

• AMPK activation is correlated with reduced fatty acid synthesis and increased fatty acid oxidation.
• There’s evidence of significantly lower systolic blood pressure.
• AICAR enhances insulin sensitivity, even in obese controls, pointing to its potential therapeutic value.

These findings are critical in understanding insulin resistance and broader metabolic disorders, suggesting that aicar treatment could pave the way for innovative approaches to metabolic health.

AICAR Peptide and Glucose Metabolism

A pivotal area of interest is how AICAR influences glucose metabolism. Experimental models demonstrate that aicar injection prior to a glucose load significantly improves insulin levels and glucose tolerance. Mechanistically, AICAR:

• Increases glucose uptake in intact cells and tissues like skeletal muscle.
• Modulates expression of genes involved in lipid metabolism and oxidative metabolism.
• Enhances insulin sensitivity by impacting signaling cascades central to muscle contraction and metabolic control.

These attributes position AICAR as a vital research tool for exploring therapeutic strategies in metabolic diseases such as type 2 diabetes and obesity.

Clinical Pharmacology and Safety Insights

While AICAR peptide is a powerful compound in research, it’s crucial to emphasize that it is not intended for human or veterinary use. All products sold by AICARPeptide.com are strictly for research purposes, consistent with regulatory standards.

Clinical pharmacology research continues to explore AICAR’s influence, with some studies appearing in prominent journals like J Biol Chem and Physiol Endocrinol Metab, further validating its significance in cellular energy regulation and metabolic disease models.

Key Mechanisms Explored Through AICAR Research

AICAR and Mitochondrial Function

One of the most compelling areas of AICAR research is its role in boosting mitochondrial function. Studies indicate that aicar treatment promotes:

• Increased oxidative metabolism
• Enhanced mitochondrial biogenesis
• Elevated endurance capacity, mimicking effects of exercise training

These findings have fueled interest in AICAR as an AMPK activator that could help elucidate pathways underlying energy metabolism and endurance adaptations.

AICAR in Adipose Tissue and Lipid Metabolism

AICAR’s influence extends into adipose tissue, where it can lead to increased expression of metabolic regulators :

• Reduce fatty acid synthesis
• Stimulate fatty acid oxidation
• Lower overall fat mass

Through activation of ampk, AICAR helps rebalance lipid pathways, highlighting its potential for research in obesity and lipid disorders.

Rat Hepatocytes and Hepatic Effects

Studies involving rat hepatocytes, isolated hepatocytes, and endothelial cells have shown that aicar administration results in significant metabolic shifts, including:

• Suppression of gluconeogenesis
• Changes in lipid metabolism
• Alterations in protein levels associated with energy balance

This positions AICAR as a valuable probe for investigating liver metabolism, a critical component of systemic metabolic homeostasis.

Research Applications and Experimental Protocols

AICARPeptide.com serves researchers who employ AICAR in diverse experimental settings, including:

• Metabolic studies in rat skeletal muscle and gastrocnemius muscles
• Analysis of insulin stimulated glucose uptake in metabolic disease models
• Exploration of mitochondrial function and oxidative metabolism
• Investigations into insulin resistance in obese Zucker rats
• Evaluation of cardiovascular parameters like systolic blood pressure

Protocols often involve:

• AICAR injection to mimic exercise-induced metabolic shifts
• Tissue freezing in liquid nitrogen for analysis of expression changes
• Biochemical assays measuring activation of AMPK and downstream signaling

Statistical analyses frequently utilize one way anova to compare control group results with experimental interventions.

Frequently Asked Questions

Q: Why Choose AICARPeptide.com?

We provide:

• High-purity AICAR peptide tested for consistency and quality
• Competitive pricing for academic and industrial researchers
• Comprehensive customer support for technical queries
• Commitment to ethical standards, emphasizing research-only applications

Our team understands the rigorous demands of scientific research. From studies on cell proliferation to whole-animal trials in obese animals, our peptides meet the highest benchmarks for reliability and performance.

Q: What is the use of AICAR peptide?

AICAR peptide, chemically known as 5-aminoimidazole-4-carboxamide ribonucleotide, is primarily used in scientific research. Its main purpose is to activate AMP-activated protein kinase (AMPK), a crucial enzyme that regulates cellular energy balance. Researchers use AICAR and its derivative aicar monophosphate to study:

• Energy metabolism in cells
• Effects on skeletal muscle glucose uptake and fatty acid oxidation
• Mechanisms of insulin sensitivity and insulin resistance
• Potential therapies for metabolic disorders like obesity, type 2 diabetes, and cardiovascular diseases

In essence, AICAR serves as a tool to mimic certain cellular effects of exercise and energy depletion, allowing scientists to explore metabolic pathways under controlled experimental conditions.

What is the drug AICAR used for?

Currently, AICAR is not an approved drug for medical treatment in humans. Instead, it’s an experimental compound used in laboratory research. Scientists investigate AICAR for its potential therapeutic benefits in conditions requiring chronic treatment :

• Enhancing glucose uptake in muscle cells
• Improving insulin sensitivity
• Reducing fat mass and influencing lipid metabolism
• Protecting the heart during ischemia (reduced blood flow)

Although there’s scientific interest in AICAR’s effects on metabolic disorders and certain cardiovascular conditions, it remains strictly a research chemical, not a prescribed medication.

Q: Can humans use AICAR?

No, humans should not use AICAR outside of research settings.

• AICAR is not approved for human or veterinary use by regulatory bodies like the FDA or EMA.
• Its safety, dosing, and side effects have not been fully evaluated for clinical use in humans.
• Any human use outside of regulated clinical trials would be illegal and potentially unsafe.

At AICARPeptide.com, we emphasize that all AICAR products are strictly for laboratory research purposes only and should be handled by qualified professionals.

Q: What is the dosage requirement for AICAR peptide?

AICAR peptide does not have a standard “dosage requirement” for humans, as there is no specific method established for its use, because it is not approved for medical or personal use. It is strictly intended for laboratory research.

In experimental settings, the dosage depends heavily on:

• Species being studied (e.g. rats, mice, cultured cells)
• Route of administration (injection vs. infusion vs. in vitro application)
• Research objectives, such as studying AMPK activation in muscle, liver, or other tissues

Examples from research:

• In rodent studies, doses can range from 0.5 mg/kg to several hundred mg/kg body weight.
• In cell culture experiments, AICAR concentrations typically range from 0.1 mM to 2.0 mM to reliably activate AMP-activated protein kinase (AMPK).

Researchers often tailor doses to achieve specific metabolic effects, such as:

• Increasing glucose uptake in skeletal muscle cells
• Enhancing fatty acid oxidation
• Mimicking effects of exercise training at a cellular level

However, these research doses cannot be translated into safe or effective doses for humans. Any attempt to use AICAR outside a lab setting is illegal and potentially hazardous.

Q: What are the side effects of AICAR peptide?

Since AICAR peptide has never been approved for human use, its side effect profile in people is unknown. However, research in animals and cell cultures has provided insights into its biological effects that could potentially lead to adverse outcomes if misused:

Possible side effects observed in animal and cellular studies include:

• Hypoglycemia or hyperglycemia: Because AICAR influences glucose uptake and insulin signaling, it may disrupt blood sugar balance.
• Altered heart function: Some studies indicate effects on systolic blood pressure and heart metabolism, especially during ischemic conditions.
• Metabolic disturbances: AICAR changes lipid metabolism, potentially lowering fatty acid synthesis while increasing fatty acid oxidation.
• Muscle fatigue or changes in muscle function: Due to shifts in energy metabolism and mitochondrial function, muscle tissues may react differently under certain conditions.
• Cellular stress: High doses in cell culture can sometimes trigger stress responses or affect cell proliferation.

None of these effects have been properly assessed in human clinical trials, and thus researchers must ensure free access to relevant data . Therefore, using AICAR peptide outside a research setting could pose serious health risks.

Q: Is AICAR legal?

AICAR peptide is legal for legitimate research purposes but strictly prohibited for human use outside the lab.

Here’s how legality breaks down:

• Research legality: In many countries, including the U.S., AICAR is legal to purchase and possess for laboratory research conducted by qualified professionals. It’s used to study AMPK activation, metabolic disorders, and the molecular biology of exercise.
• Human consumption: It is illegal to market, sell, or distribute AICAR peptide for human consumption, supplementation, or therapeutic purposes. It’s not approved by agencies like the FDA or EMA for medical use.
• Sports regulations: The World Anti-Doping Agency (WADA) classifies AICAR as a prohibited substance under its “Metabolic Modulators” category. Athletes caught using AICAR face sanctions for doping violations because it could enhance endurance and mimic training adaptations.
• Sale and marketing: Selling AICAR peptide as a dietary supplement or performance-enhancing drug is illegal and may lead to severe penalties for companies and individuals.

Q: Do AMPK activators really work?

Yes — in research models, AMPK activators like AICAR do work to trigger cellular changes.

• AICAR and other AMPK activators have been shown in studies to:
  • Increase glucose uptake in muscle and other tissues
  • Stimulate fatty acid oxidation
  • Improve markers of insulin sensitivity
  • Mimic some of the benefits of exercise training

However, translating these effects into safe, effective human treatments remains a challenge. Many compounds that activate AMPK in cell cultures or animal studies have not yet proven safe or effective as drugs for human use.

Researchers continue to explore AMPK activators for possible therapies in metabolic diseases, obesity, type 2 diabetes, and even aging — but as of today, no AMPK activator is approved as a medicine for humans.

Stay Informed with AICARPeptide.com

We believe that knowledge empowers progress. Explore our site for:

• Educational resources on aicar treatment and ampk activation
• Protocol tips for working with 5 aminoimidazole 4 carboxamide derivatives
• Updates on research into energy metabolism, exercise, and metabolic disorders

Whether you’re studying metabolic adaptations in obese controls, testing interventions to improve insulin sensitivity, or mapping cellular energy pathways, AICARPeptide.com is your reliable partner.

Disclaimer

All products offered by AICARPeptide.com are for laboratory research purposes only. They are not intended for human or veterinary use and should be handled only by qualified personnel.

Explore Our Products and Resources Today

Ready to advance your research? Visit our product pages to learn more about our premium-quality AICAR peptide, a powerful tool for exploring the intricate world of AMPK activation, muscle metabolism, and beyond.

Let’s unlock new discoveries in the science of metabolic regulation—together.